the effect of repeated transfusions on immunoglobulins levels and complement components in beta thalassemia major patients
نویسندگان
چکیده
beta thalassemia major patients receive repeated transfusions in order to compensate anemia and use desferal to remove iron overload. comparing immunoglobulins and complement components in the serum of these patients with normal range shows a significant increase (p<0.001) in igg, iga and igm and a decrease in c3c and c4. the regression analysis confirms a relation between the numbers of transfusions and the mentioned immunological factors that means increasing the number of transfusions, increases immunoglobulins and decreases the complement. also, this evaluation shows that use of washed rbc and regular in take of desferal will prevent excessive increase of immunoglobulins or decrease of complement
منابع مشابه
Influence of splenectomy on immunoglobulins and complement components in major thalassemia
Abstract Introduction: Thalassemia is the most common hereditary anemia in Iran. The aim of this study was to evaluate the humoral immune system and assess the effect of splenectomy on the serum level of immunoglobulins IgG, IgM, and IgA and complement components in patients with major thalassemia. Materials and Methods: This interventional semi-experimental study (before-after) was performed...
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Beta Thalassemia major patients receive repeated transfusions in order to compensate anemia and use desferal to remove iron overload. Comparing immunoglobulins and complement components in the serum of these patients with normal range shows a significant increase (P<0.001) in IgG, IgA and IgM and a decrease in C3c and C4. The regression analysis confirms a relation between the numbers of transf...
متن کاملinfluence of splenectomy on immunoglobulins and complement components in major thalassemia
abstract introduction: thalassemia is the most common hereditary anemia in iran. the aim of this study was to evaluate the humoral immune system and assess the effect of splenectomy on the serum level of immunoglobulins igg, igm, and iga and complement components in patients with major thalassemia. materials and methods: this interventional semi-experimental study (before-after) was performed o...
متن کاملInfluence of splenectomy on immunoglobulins and complement components in major thalassemia
BACKGROUND Thalassemia is the most common anemia with hereditary base in Iran. The aim of this study was to evaluate the humoral immune system and assess the effect of splenectomy on the serum level of immunoglobulins IgG, IgM, and IgG and complement components in patients with major thalassemia. METHODS This quasi-experimental study (before-after) was performed on 40 patients with major thal...
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Introduction: Nowadays one of the most important problems of Thalassemia major patients is the additional load of iron and hemosiderosis, the most important consequence of which is deposited iron in myocardial tissue and the incidence of cardiomyopathy caused by hemochromatosis. The aim of this study was to determine the effect of concurrent (resistance-endurance) exercise on NT-pro BNP and...
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عنوان ژورنال:
مجله دانشکده پزشکی دانشگاه علوم پزشکی تهرانجلد ۵۴، شماره ۱، صفحات ۵۸-۶۲
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